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I.

1.1. - " " ( - ) , , .
1.2. " - " ( , 1999, 14, . 1650), " " ( , 2000, 2, . 150), " " ( 17 1996 .), " " ( , 1996, 3, . 140), " " ( , 1993, 33, . 1318), 24 2000 . 554 " - - " ( , 2000, 31, . 3295).
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II.

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IV.


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Trichoderma reesei
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Thermomyces lanuginosus
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Saccharomyces cerevisiae ,
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Aspergillus niger
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,

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Aspergillus niger, var. -
Aspergillus awamori, var.
Bacillus licheniformis
Rhizopus oryzae, var.
Saccharomyces spp.
+--+-------------------+--------------------------+------------------------------+---------------------+
Micrococcus lysodeikticus Aspergillus niger - -
Aspergillus niger
+--+-------------------+--------------------------+------------------------------+---------------------+
Penicillium funiculosum Trichoderma reesei-d-
Trichoderma reesei Trichoderma reesei
Trichoderma viride
Aspergillus niger
Aspergillus aculeatus
+--+-------------------+--------------------------+------------------------------+---------------------+
A () E. coli K-12 IA 198,


,

A,
PPFZ-87A
+--+-------------------+--------------------------+------------------------------+---------------------+
A Aspergillus niger var.
awamori, .
(NRRZ3112)
- pgAMpR
+--+-------------------+--------------------------+------------------------------+---------------------+
B Kluyveromyces lactis Kluyveromyces lactis
(Dombr. Van del Walt)
,

PUC18
+--+-------------------+--------------------------+------------------------------+---------------------+
B Trichoderma reesei,

B
+--+-------------------+--------------------------+------------------------------+---------------------+
B- Aspergillus niger var.
Trichoderma harzianum
Trichoderma reesei -
longibrachiatum
Talaromyces emersonii Trichoderma sp.
B. subtilis
amyloliquefaciences Bacillus sp.
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dimorimorphosporum
+--+-------------------+--------------------------+------------------------------+---------------------+
B. coagulans,
Streptomyces olivaceous,
Streptomyces rubiginosus,
Streptomyces
violaceoniger
+--+-------------------+--------------------------+------------------------------+---------------------+
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Aspergillus niger
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+--+-------------------+--------------------------+------------------------------+---------------------+
-
Candida antarctica ,
Rhizomucor spp.
Aspergillus oryzae Thermomyces spp.
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Rhizopus niveus Candida antarctica
Penicillium roquefortii Aspergillus oryzae
Penicillium camembertii Rhizomucor miehei
Mucor javanicus Aspergillus oryzae
Rhizomucor miehei Fusarium oxysporum
Fusarium oxysporum Aspergillus oryzae ,
Termomyces lanuginosus
Termomyces lanuginosus
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Aspergillus niger Aspergillus oryzae d-
Rhizopus oryzae Aspergillus aculeatus
Aspergillus aculeatus Aspergillus niger d-
Aspergillus oryzae Aspergillus niger
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Aspergillus oryzae. Bacillus subtilis d-
Aspergillus melleus B. amyloliquefaciens
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Rhizopus oryzae
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Klebsiella planticola
+--+-------------------+--------------------------+------------------------------+---------------------+
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Cryphonectria parasitica
Aspergillus oryzae
+--+-------------------+--------------------------+------------------------------+---------------------+
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+-

+--+-------------------+--------------------------+------------------------------+---------------------+
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+--+-------------------+--------------------------+------------------------------+---------------------+
- B. subtilus UW-193
- -
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- B. brevis

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Aspergillus niger - Bacillus spp.
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Candida pseudotropicalis lactis d-Kluyveromyces
Kluyveromyces marxianus marxianus var. lactis
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Aspergillus oryzae
+--+-------------------+--------------------------+------------------------------+---------------------+
Aspergillus niger Fusarium venetatum
Aspergillus oryzae Thermomyces lanuginosum
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subtilis Thermomyces lanuginosus
B. licheniformis Bacillus subtilis d-
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longibrachiatum Trichoderma reesei d-
Trichoderma reesei
Aspergillus niger var. awamori
d-Aspergillus var.
Aspergillus niger d-
Aspergillus niger
+--+-------------------+--------------------------+------------------------------+---------------------+
Saccharomyces cerevisiae -
+--+-------------------+--------------------------+------------------------------+---------------------+
Lactobacillus amylovorus Aspergillus niger d-
Aspergillus niger Aspergillus niger
Aspergillus oryzae
Rhizopus oryzae
Rhizopus niveus
Rhizopus delemar
Penicillium funiculosum
+--+-------------------+--------------------------+------------------------------+---------------------+
Trichoderma reesei -
longibrachiatum Aspergillus spp.
Aspergillus niger
Aspergillus oryzae
+--+-------------------+--------------------------+------------------------------+---------------------+
Aspergillus niger -
Aspergillus niger
+--+-------------------+--------------------------+------------------------------+---------------------+
-B. licheniformis -
Thermoanaerobacter
+--+-------------------+--------------------------+------------------------------+---------------------+
Aspergillus niger -
Aspergillus spp.
+--+-------------------+--------------------------+------------------------------+---------------------+
Streptomyces livadans
Streptomyces rubiginosus
Actinoplanes missouriensis
Streptomyces
olivochromogenes Streptomyces rubiginosus d-
Streptomyces murimus Streptomyces rubiginosus
Streptomyces olivaceus
Microbacterium
arborescens
Actinoplane missouriensis
Bacillus coagulans
+--+-------------------+--------------------------+------------------------------+---------------------+
Aspergillus niger
Trichoderma reesei
Aspergillus aculeatus -
Aspergillus foetidus Bacillus spp.
B. amyloliquefaciens
subtilis
+--+-------------------+--------------------------+------------------------------+---------------------+
B. amyloliquefaciens -
subtilis Bacillus spp.
+--+-------------------+--------------------------+------------------------------+---------------------+
Aspergillus niger -
Trichoderma reesei Aspergillus spp.
longibrachiatum
+--+-------------------+--------------------------+------------------------------+---------------------+
Trichoderma reesei -
longibrachiatum Aspergillus spp.
Aspergillus aculeatus Aspergillus oryzae ,

Aspergillus aculeatus
+--+-------------------+--------------------------+------------------------------+---------------------+
A Trichoderma reesei -
longibrachiatum Aspergillus spp.
+--+-------------------+--------------------------+------------------------------+---------------------+
B Trichoderma reesei -
longibrachiatum Aspergillus spp.
+--+-------------------+--------------------------+------------------------------+---------------------+
A2 Streptomyces violaceruber
2

+--+-------------------+--------------------------+------------------------------+---------------------+
A2 Aspergillus niger Aspergillus niger PLA-54
, ,

Aspergillus niger GAM-53


Aspergillus niger PLA-54
,
A2 Aspergillus
niger GAM-53 (NRRL3122
Aspergillus niger)
+--+-------------------+--------------------------+------------------------------+---------------------+
C Pichia pastoris C


+--+-------------------+--------------------------+------------------------------+---------------------+
- Trichoderma reesei Aspergillus niger EPG-102
longibrachiatum ,
Aspergillus niger
Aspergillus niger GAM-53
NRRL3122 Aspergillus niger
+--+-------------------+--------------------------+------------------------------+---------------------+
Bacillus licheniformis -
Bacillus subtilis Bacillus spp.
Bacillus deramificans Klebsiella spp.
18-I T13 13 B. subtilis
Klebsiella planticola
B. acidopullulyticus
A1645
Bacillus subtilis
Bacillus
deramificans 18-INT13
+--+-------------------+--------------------------+------------------------------+---------------------+
Aspergillus niger Aspergillus niger d-
Aspergillus niger ,



+--+-------------------+--------------------------+------------------------------+---------------------+
Aspergillus oryzae A. oryzae
A. oryzae
+--+-------------------+--------------------------+------------------------------+---------------------+
Saccharomyces cerevisiae
ECMo01


+--+-------------------+--------------------------+------------------------------+---------------------+
Bacillus subtilis
+--+-------------------+--------------------------+------------------------------+---------------------+
B-D- Aspergillus niger
Trichoderma reesei
+--+-------------------+--------------------------+------------------------------+---------------------+
Lactobacillus fermentum
+--+-------------------+--------------------------+------------------------------+---------------------+
-Morteirella vinaceae var. -
raffinoseutilizer
+--+-------------------+--------------------------+------------------------------+---------------------+
,
+--+-------------------T--------------------------T------------------------------T---------------------+
Streptomyces griseus B. subtilus ,

+--+-------------------+--------------------------+------------------------------+---------------------+
- Blakeslea trispora, ,

(+) (-)
+--+-------------------+--------------------------+------------------------------+---------------------+
( Lactococcus lactis subs. Lactococcus lactis subs. ,
E-234) lactis lactis ,

+--+-------------------+--------------------------+------------------------------+---------------------+
Blakeslea trispora ,

+--+-------------------+--------------------------+------------------------------+---------------------+
Candida guilliermondii
Candida lipolytica
Aspergillus niger
L--+-------------------+--------------------------+------------------------------+----------------------


3

,


   ------------------------------------T-------------------------------------

(, ,
)
+-----------------------------------+-------------------------------------+

+-----------------------------------T-------------------------------------+
Lactococcus lactis subsp. lactis Lactococcus,
- Lactococcus,
:
1. ,
2. ,
3. -,
4. -,
5.
Propionibacterium shermani,
6.
+-----------------------------------+-------------------------------------+
Lactococcus lactis subsp. cremoris -
+-----------------------------------+-------------------------------------+
Lactococcus lactis subsp. lactis -
biovar diacetilactis
+-----------------------------------+-------------------------------------+

+-----------------------------------T-------------------------------------+
Leuconostoc lactis -
+-----------------------------------+-------------------------------------+
Leuconostoc mesenteroides subsp. -

dextranicum
+-----------------------------------+-------------------------------------+
Leuconostoc mesenteroides subsp. -

mesenteroides
+-----------------------------------+-------------------------------------+

+-----------------------------------T-------------------------------------+
Streptococcus salivarius -
+-----------------------------------+-------------------------------------+
Streptococcus thermophilus S. thermophilus,
; S. thermophilus,
-

+-----------------------------------+-------------------------------------+
Lactobacillus
+-----------------------------------T-------------------------------------+
Lactobacillus acidophilus ,
Lactobacillus acidophilus,

+-----------------------------------+-------------------------------------+
Lactobacillus alimentarius -
+-----------------------------------+-------------------------------------+
Lactobacillus amylovorus -
Aspergillus spp.
+-----------------------------------+-------------------------------------+
Lactobacillus bavaricus -
+-----------------------------------+-------------------------------------+
Lactobacillus brevis -
+-----------------------------------+-------------------------------------+
Lactobacillus buchneri -
+-----------------------------------+-------------------------------------+
Lactobacillus casei ,
Lactobacillus spp.,

pH
+-----------------------------------+-------------------------------------+
Lactobacillus casei 1. L. casei
- . coli
2 L. casei
Zymomonas
mobilis
3. L. casei -
E. coli
4. L. casei
Streptomyces spp.
+-----------------------------------+-------------------------------------+
Lactobacillus casei, subsp. -
rhamnosus GG
+-----------------------------------+-------------------------------------+
Lactobacillus coryneformis
+-----------------------------------+-------------------------------------+
Lactobacillus curvatus

+-----------------------------------+-------------------------------------+
Lactobacillus crispatus
+-----------------------------------+-------------------------------------+
Lactobacillus delbruecki subsp. -
delbrueckii
+-----------------------------------+-------------------------------------+
Lactobacillus delbrueckii subsp. -
Bulgaricus
+-----------------------------------+-------------------------------------+
Lactobacillus delbrueckii subsp. -
Lactis
+-----------------------------------+-------------------------------------+
Lactobacillus farciminis -
+-----------------------------------+-------------------------------------+
Lactobacillus fermentum -
+-----------------------------------+-------------------------------------+
Lactobacillus gasseri 1. L. gasseri msd E. coli


2. L. gasseri

3. ,
Clostridium
thermocellum
+-----------------------------------+-------------------------------------+
Lactobacillus johnsonii ,
Clostridium thermocellum
+-----------------------------------+-------------------------------------+
Lactobacillus helveticus


+-----------------------------------+-------------------------------------+
Lactobacillus heterohiochi -
(= L. fructivorans)
+-----------------------------------+-------------------------------------+
Lactobacillus hilgardii -
+-----------------------------------+-------------------------------------+
Lactobacillus xylosus (= L. lactis ,
subsp. lactis)
Lactobacillus spp.
+-----------------------------------+-------------------------------------+
Lactobacillus zeae (= L. casei -
subsp. casei/L. rhamnosus)
+-----------------------------------+-------------------------------------+
Lactobacillus sakei subsp. sakei

+-----------------------------------+-------------------------------------+
Lactobacillus sakei subsp. carnosus,
(= L. curvatus) Lactobacillus sakei
+-----------------------------------+-------------------------------------+
Lactobacillus salivarius -
+-----------------------------------+-------------------------------------+
Lactobacillus sanfrancisco -
(= L. sanfranciscensis)
+-----------------------------------+-------------------------------------+
Lactobacillus sanfranciscensis -
(= L. sanfrancisco)
+-----------------------------------+-------------------------------------+
Lactobacillus kefirgranum
+-----------------------------------+-------------------------------------+
Lactobacillus kefiri -
+-----------------------------------+-------------------------------------+
Lactobacillus lactis -
+-----------------------------------+-------------------------------------+
Lactobacillus paracasei -
+-----------------------------------+-------------------------------------+
Lactobacillus pentosus -
+-----------------------------------+-------------------------------------+
Lactobacillus plantarum :
1. ,

2. -
L. amylovorus
3. ,

4.
+-----------------------------------+-------------------------------------+
Lactobacillus reuteri ,
Neocallimastix patriciarum,
- Fibrobacter
succinogenes,
Piromyces rhizinflata
+-----------------------------------+-------------------------------------+
Lactobacillus rhamnosus -
+-----------------------------------+-------------------------------------+
, , :
+-----------------------------------T-------------------------------------+
Staphylococcus carnosus
+-----------------------------------+-------------------------------------+
Staphylococcus carnosus subsp. -
carnosus
+-----------------------------------+-------------------------------------+
Staphylococcus carnosus subsp. -
utilis (= S. carnosus)
+-----------------------------------+-------------------------------------+
Staphylococcus equorum -
+-----------------------------------+-------------------------------------+
Staphylococcus sciuri -
+-----------------------------------+-------------------------------------+
Staphylococcus xylosus -
+-----------------------------------+-------------------------------------+
Staphylococcus vitulinus -
(= S. pulveri)
+-----------------------------------+-------------------------------------+
Brevibacterium casei -
+-----------------------------------+-------------------------------------+
Brevibacterium linens -
+-----------------------------------+-------------------------------------+
Pediococcus acidilactici -
+-----------------------------------+-------------------------------------+
Pediococcus pentosaceus -
+-----------------------------------+-------------------------------------+
Corynebacterium
+-----------------------------------T-------------------------------------+
Corymbacterium ammoniagenes -
+-----------------------------------+-------------------------------------+
Corynebacterium flavescens -
+-----------------------------------+-------------------------------------+
Enterococcus
+-----------------------------------T-------------------------------------+
Enterococcus durans -
+-----------------------------------+-------------------------------------+
Enterococcus faecium -
+-----------------------------------+-------------------------------------+
Arthrobacter
+-----------------------------------T-------------------------------------+
Arthrobacter nicotianae -
+-----------------------------------+-------------------------------------+
Acetobacter
+-----------------------------------T-------------------------------------+
Acetobacter xylinum -
+-----------------------------------+-------------------------------------+
Acetobacter suboxydans -
+-----------------------------------+-------------------------------------+
Acetobacter aceti -
+-----------------------------------+-------------------------------------+
Propionibacterium
+-----------------------------------T-------------------------------------+
Propionibacterium acidipropionici -
+-----------------------------------+-------------------------------------+
Propionibacterium arabinosum -
+-----------------------------------+-------------------------------------+
Propionibacterium freudenreichii
subsp. freudenreichii Propionibacterium freudenreichii
T1
+-----------------------------------+-------------------------------------+
Propionibacterium freudenreichii -
subsp. shermanii
+-----------------------------------+-------------------------------------+
Propionibacterium thoenii -
+-----------------------------------+-------------------------------------+
Bifidobacterium
+-----------------------------------T-------------------------------------+
Bifidobacterium adolescentis -
+-----------------------------------+-------------------------------------+
Bifidobacterium animalis -
+-----------------------------------+-------------------------------------+
Bifidobacterium bifidum -
+-----------------------------------+-------------------------------------+
Bifidobacterium breve -
+-----------------------------------+-------------------------------------+
Bifidobacterium infantis -
+-----------------------------------+-------------------------------------+
Bifidobacterium lactis = -
(B. animalis)
+-----------------------------------+-------------------------------------+
Bifidobacterium longum <**> B. longum-
Escherichia coli
+-----------------------------------+-------------------------------------+
Bifidobacterium pseudolongum -
+-----------------------------------+-------------------------------------+
Bacillus
+-----------------------------------T-------------------------------------+
B. cereus -
+-----------------------------------+-------------------------------------+
Bacillus coagulans -
(= . Lactobacillus
sporogenes)
+-----------------------------------+-------------------------------------+
Bacillus licheniformis -
Thermoanaerobacter
+-----------------------------------+-------------------------------------+
B. mesentericus -
+-----------------------------------+-------------------------------------+
B. subtilis amyloliquefaciences-
+-----------------------------------+-------------------------------------+
B. amyloliquefaciences B. amyloliquefaciences
B. subtilis
+-----------------------------------+-------------------------------------+
Bacillus amyloliquefaciencs Bacillus amyloliquefaciencs
1. , -
Bacillus amyloliquefaciencs
2.
Bacillus amyloliquefaciencs
+-----------------------------------+-------------------------------------+
Bacillus licheniformis B. licheniformis -
B. stearothermophilus
+-----------------------------------+-------------------------------------+
Bacillus licheniformis B. licheniformis
- B.
licheniformis
+-----------------------------------+-------------------------------------+
Bacillus licheniformis Bacillus licheniformis ,
Bacillus
deramificans
+-----------------------------------+-------------------------------------+
B. subtilis B. subtilus UW-193 -
B. brevis ...
PUW 235
+-----------------------------------+-------------------------------------+
B. subtilis B. subtilis -
. brevis
+-----------------------------------+-------------------------------------+
B. subtilis Bacillus subtilis ,
Bacillus deramificans
+-----------------------------------+-------------------------------------+
B. subtilis B. subtilus

+-----------------------------------+-------------------------------------+
B. subtilis B. subtilis B.
stearothermophilus, B. subtilis
. brevis
+-----------------------------------+-------------------------------------+
Bacillus subtilis B. subtilis B.
acidopullulyticus
+-----------------------------------+-------------------------------------+
B. subtilis . F B. subtilis -
B. megaterium,
800
2. B. subtilis -
B. stearothermophilus,
720
+-----------------------------------+-------------------------------------+
B. stearothermophilus -
+-----------------------------------+-------------------------------------+
B. thermortotyolyticus -
+-----------------------------------+-------------------------------------+
Micrococcus
+-----------------------------------T-------------------------------------+
Micrococcus varians (= Kucuria -
varians)
+-----------------------------------+-------------------------------------+
Micrococcus lysodeicticus -
+-----------------------------------+-------------------------------------+
E. coli
+-----------------------------------T-------------------------------------+
E. coli E. coli -12 IA 198,

,
A,
PPFZ-87A
+-----------------------------------+-------------------------------------+
Klebsiella
+-----------------------------------T-------------------------------------+
Klebsiella alrogenes -
+-----------------------------------+-------------------------------------+
Klebsiella planticola Klebsiella spp.
+-----------------------------------+-------------------------------------+
Thermococcales Pseudomonas fluorescens

+-----------------------------------+-------------------------------------+
()
+-------------------------------------------------------------------------+
Fusarium
+-----------------------------------T-------------------------------------+
Fusarium solani -
+-----------------------------------+-------------------------------------+
Fusarium venetatum Fusarium venetatum
Thermomyces lanuginosum
- Aspergillus sp.
Thermomyces sp.
Trichoderma spp., Bacillus spp.
+-----------------------------------+-------------------------------------+
Aspergillus
+-----------------------------------T-------------------------------------+
Aspergillus niger -
+-----------------------------------+-------------------------------------+
Aspergillus niger Aspergillus niger var. awamori,
.
(NRRZ3112)
- pgAMpR A. niger
Candida antarctica
Aspergillus niger, ,

Aspergillus niger
l. c Aspergillus niger,

2. Aspergillus niger,
-1,4-

3. A.
nidulans
4. ,

Aspergillus niger
5. Aspergillus niger,


6. Aspergillus niger,

7. Aspergillus niger,


8. Aspergillus niger,

+-----------------------------------+-------------------------------------+
B. amyloliquefaciens subtilis -
Bacillus spp.
+-----------------------------------+-------------------------------------+
Aspergillus awamori -
+-----------------------------------+-------------------------------------+
Aspergillus oryzae Aspergillus oryzae,
:
1. -
Aspergillus aculeatus Thermomyces
lanuginosus
2. - Humicola
lanuginosa
3. Myceliophthora
thermophilus
4. 1 Fusarium
venetatum
5. Aspergillus
niger
6. Thermomyces lanuginosus
Fusarium oxysporum
7. - Rhizomucor
miehei
8. Aspergillus sojae
+-----------------------------------+-------------------------------------+
Aspergillus oryzae A. oryzae A.
oryzae
+-----------------------------------+-------------------------------------+
Aspergillus oryzae var. -
Candida sp.
Rhizomucor sp. Thermomyces sp.
+-----------------------------------+-------------------------------------+
Penicillium
+-----------------------------------T-------------------------------------+
Penicillium album (= P. caseicolum,-
P.candidum, or P. camembertii)
+-----------------------------------+-------------------------------------+
Penicillium camembertii -
(= P. caseicolum, P. candidum, or
P. album)
+-----------------------------------+-------------------------------------+
Penicillium candidum -
(= P. caseicolum, P. camembertii,
P. album)
+-----------------------------------+-------------------------------------+
Penicillium funiculosum -
+-----------------------------------+-------------------------------------+
Penicillium roquefortii -
+-----------------------------------+-------------------------------------+
Verticillium
+-----------------------------------T-------------------------------------+
Verticillium lecanii -
+-----------------------------------+-------------------------------------+
Trichoderma
+-----------------------------------T-------------------------------------+
Trichoderma reesei -
longibrachiatum
+-----------------------------------+-------------------------------------+
Trichoderma reesei T. reesei,

+-----------------------------------+-------------------------------------+
Trichoderma harzianum -
+-----------------------------------+-------------------------------------+
Trichothecium
+-----------------------------------T-------------------------------------+
Trichothecium domesticum -
+-----------------------------------+-------------------------------------+
Humicola
+-----------------------------------T-------------------------------------+
Humicola insolens -
+-----------------------------------+-------------------------------------+
Rhizopus
+-----------------------------------T-------------------------------------+
Rhizopus arrhizus -
+-----------------------------------+-------------------------------------+
Rhizophus niveus -
+-----------------------------------+-------------------------------------+
Rhizophus oryzae -
+-----------------------------------+-------------------------------------+
Rhizopus oryzae, -
var. Sacharomyces spp.
+-----------------------------------+-------------------------------------+
Mucor
+-----------------------------------T-------------------------------------+
Mucor miehei -
+-----------------------------------+-------------------------------------+
Mucor pusillus -
+-----------------------------------+-------------------------------------+
Mucor lusitanicus -
+-----------------------------------+-------------------------------------+
Rhizomucor
+-----------------------------------T-------------------------------------+
Rhizomucor miehei -
+-----------------------------------+-------------------------------------+
Rhizomucor pusillus -
+-----------------------------------+-------------------------------------+
Streptomyces
+-----------------------------------T-------------------------------------+
Streptomyces olivaceous -
+-----------------------------------+-------------------------------------+
Streptomyces rubiginosus -
Streptomyces spp.
Acinoplanes spp.
+-----------------------------------+-------------------------------------+
Streptomyces rubiginosus Streptomyces rubiginosus ,
-
Streptomyces rubiginosus
+-----------------------------------+-------------------------------------+
Streptomyces violaceoniger S. violaceoniger ,
,
A2
+-----------------------------------+-------------------------------------+
Streptomyces fradias -
+-----------------------------------+-------------------------------------+
Streptomyces livadans -
Streptomyces spp.
Acinoplanes spp.
+-----------------------------------+-------------------------------------+
Actinoplanes
+-----------------------------------T-------------------------------------+
Actinoplanes missiouriensis -
+-----------------------------------+-------------------------------------+
-
+-----------------------------------+-------------------------------------+
Blakeslea
+-----------------------------------T-------------------------------------+
Blakeslea trispora Blakeslea trispora,
(+)
(-)
+-----------------------------------+-------------------------------------+

+-------------------------------------------------------------------------+
Saccharomyces
+-----------------------------------T-------------------------------------+
Saccharomyces bayanus -
+-----------------------------------+-------------------------------------+
Saccharomyces cerevisiae ,
Saccharomyces diastaticus
+-----------------------------------+-------------------------------------+
Saccharomyces cerevisiae S. cerevisieae Y-1986 -
B. licheniformis
+-----------------------------------+-------------------------------------+
Saccharomyces cerevisiae S. cerevisiae ECMo01

+-----------------------------------+-------------------------------------+
Saccharomyces cerevisiae subsp. -
boulardii
+-----------------------------------+-------------------------------------+
Saccharomyces florentius -
+-----------------------------------+-------------------------------------+
Saccharomyces fragilis -
+-----------------------------------+-------------------------------------+
Saccharomyces lactis -
+-----------------------------------+-------------------------------------+
Saccharomyces unisporus -
+-----------------------------------+-------------------------------------+
Kluyveromyces
+-----------------------------------T-------------------------------------+
Kluyveromyces fragilis -
(= Kluyveromyces marxianus)
+-----------------------------------+-------------------------------------+
Kluyveromyces lactis Kluyvenomyces lactis (Dombr. Van del
Walt) ,
PUC18


+-----------------------------------+-------------------------------------+
Kluyveromyces marxianus -
(= Kluyveromyces fragilis)
+-----------------------------------+-------------------------------------+
Hansenula
+-----------------------------------T-------------------------------------+
Hansenula mrakii -
(= Williopsis mrakii)
+-----------------------------------+-------------------------------------+
Candida
+-----------------------------------T-------------------------------------+
Candida famata -
+-----------------------------------+-------------------------------------+
Candida kefyr -
(= C. pseudotropicalis)
+-----------------------------------+-------------------------------------+
Candida friedricchi -
+-----------------------------------+-------------------------------------+
Candida holmii -
+-----------------------------------+-------------------------------------+
Candida krusei -
+-----------------------------------+-------------------------------------+
Candida pseudotropicalis -
(= C. kefyr)
+-----------------------------------+-------------------------------------+
Candida utilis -
+-----------------------------------+-------------------------------------+
Candida valida -
+-----------------------------------+-------------------------------------+
Debaryomyces
+-----------------------------------T-------------------------------------+
Debaryomyces hansenii -
+-----------------------------------+-------------------------------------+
Geotrichum
+-----------------------------------T-------------------------------------+
Geotrichum candidum -
+-----------------------------------+-------------------------------------+
Williopsis
+-----------------------------------T-------------------------------------+
Williopsis mrakii -
(= Hansenula mrakii)
+-----------------------------------+-------------------------------------+
Pichia
+-----------------------------------T-------------------------------------+
Pichia pastoris -
+-----------------------------------+-------------------------------------+
Carnobacterium maltaromaticum -
+-----------------------------------+-------------------------------------+
Morteirella vinaceae var. -
raffinoseutilizer
+-----------------------------------+-------------------------------------+
Pseudomonas fluorescens Pseudomonas fluorescens
Thermococcales
L-----------------------------------+--------------------------------------


"-" - .

5.5. , , :
) :
- ;
- - , , , ;
- - , , ;
) :
- , , , , ;
- , ( ); ;
- , ;
- , , ;
- ;
- ;
- ;
- - ;
- ;
- ;
- , ;
- , - .
5.6. - / :
) ;
) , ( , ) / , . ;
) ( ) , () , / , ( , ; ; , , , , / ).
5.6.1. ; , . , .
5.6.2. ( 7), .
5.6.3. () , / (), , -, .
5.6.4. - , , (- ) , - - .
5.7. - , / - , :
5.7.1. () , :
- - ;
- -;
- ;
- . 2.18 .
5.7.2. , (), ( ) , - .
5.7.3. - / - .
5.7.4. , 1, (/ , , ), (. 5.6.1) - , ( III - - ).
5.8. , / , , .
5.8.1. / , - - .
5.8.2. - / .
5.8.3. , / , :
) ( - ), , , , , (-, ), ;
) ;
) ( , ).
5.8.4. , :
) " " - , ;
) " " - ( ) - 1 ( , , - -); , / , - ( ); - , , , , ;
) "" - . 2.18 ;
) - , ( - , ), ( () / ; - , ); , - , - , , - () .
   ------------------------------------------------------------------

--> .
, , : . 5.7 . , "" 5.6.
   ------------------------------------------------------------------

5.8.5. / , - . 5.7 "".
5.8.6. :
) (, , ), , , , - , , ( , -) - , , ;
) - - () ;
) , , , , .
5.9. , / , , , - (, , , ), - , .
5.9.1. - , / , , , / , - . 5.6 "".
5.9.2. , , , , , , .
5.9.3. , , , . . 5.8.4 "" 5.8.6 "".
5.10. - , / , , :
5.10.1. , , , , , 4 - .

4




   --------------------------------------T-----------------------------------


-

+-------------------------------------+-----------------------------------+
:
+-------------------------------------+-----------------------------------+
0,5
(, ..) <*>

+-------------------------------------+-----------------------------------+
<*> 0,5
2
250
+-------------------------------------+-----------------------------------+
, <*> 200


+-------------------------------------+-----------------------------------+
<*>0,5
2 0,5
+-------------------------------------+-----------------------------------+
<*> 200
+-------------------------------------+-----------------------------------+
<*> 300
1 200
+-------------------------------------+-----------------------------------+
, , 200
.. <*> 1 200
+-------------------------------------+-----------------------------------+
200
+-------------------------------------+-----------------------------------+
, 200

+-------------------------------------+-----------------------------------+
:
+-------------------------------------+-----------------------------------+
400
+-------------------------------------+-----------------------------------+
500
+-------------------------------------+-----------------------------------+
,
,
:
+-------------------------------------+-----------------------------------+
, 3 1 ,
1 1 ,
- 125
+-------------------------------------+-----------------------------------+
, 500
, ,

+-------------------------------------+-----------------------------------+
:
+-------------------------------------+-----------------------------------+
, , 0,5
+-------------------------------------+-----------------------------------+
(, ) 1 0,5
+-------------------------------------+-----------------------------------+

- 0,5
- 0,5
+-------------------------------------+-----------------------------------+
, 1 ( - 200 )
+-------------------------------------+-----------------------------------+
:
+-------------------------------------+-----------------------------------+
, , (, 500
, , )
+-------------------------------------+-----------------------------------+
,
:
+-------------------------------------+-----------------------------------+
, 2 ( 500 )
+-------------------------------------+-----------------------------------+
. - 3 .
( 300 )
+-------------------------------------+-----------------------------------+
: ,500
, , , ,
, ,
,
+-------------------------------------+-----------------------------------+
:
+-------------------------------------+-----------------------------------+
300 1
+-------------------------------------+-----------------------------------+
, , 200

+-------------------------------------+-----------------------------------+
:
+-------------------------------------+-----------------------------------+



+-------------------------------------+-----------------------------------+
200
200
+-------------------------------------+-----------------------------------+
, 200

(, .)
+-------------------------------------+-----------------------------------+

:
+-------------------------------------+-----------------------------------+
,


200
200
+-------------------------------------+-----------------------------------+
:
+-------------------------------------+-----------------------------------+
, 200
+-------------------------------------+-----------------------------------+
3 200
,
,
,

+-------------------------------------+-----------------------------------+


50
200
+-------------------------------------+-----------------------------------+
,
, ,

, .. 200
50
+-------------------------------------+-----------------------------------+


, .. 200
50
+-------------------------------------+-----------------------------------+
, , 100


+-------------------------------------+-----------------------------------+
:
+-------------------------------------+-----------------------------------+
100
+-------------------------------------+-----------------------------------+
200 , 100 , 0,5 , 0,5 , 300
(, ,
, , )
+-------------------------------------+-----------------------------------+
100
( , 1
, , ,
..)
L-------------------------------------+------------------------------------


   --------------------------------

<*> .

5.10.2. , .
5.10.3. 5.3 2 3:
- , ;
- , ;
- , -- .
5.10.4. - / - ( 1).
5.10.5. , - , , ( ) , - .
5.10.6. - .
5.10.7. , 5 6.

5




   ---------T---------------------------T------------------------T------------T-------------

I II III
<*> +------------------------+------------+-------------+
,
-

+-----------T------------+
,
-

+--------+---------------------------+-----------+------------+------------+-------------+

+--------T---------------------------T-----------T------------T------------T-------------+
(), + + - -
1


-

+--------+---------------------------+-----------+------------+------------+-------------+
- - + +
-
+--------+---------------------------+-----------+------------+------------+-------------+
+ + - -
,
<*>
+--------+---------------------------+-----------+------------+------------+-------------+
-
+--------T---------------------------T-----------T------------T------------T-------------+
+ + + +
()
(),

-
, ..
-
<*>
+--------+---------------------------+-----------+------------+------------+-------------+
+ + + + <*>

(
.) (),


+--------+---------------------------+-----------+------------+------------+-------------+
- + + + <*>
-"-
<*>
+--------+---------------------------+-----------+------------+------------+-------------+
- + + + <*>
-"-
+--------+---------------------------+-----------+------------+------------+-------------+
̦ + + - -
(),

- <*>
+--------+---------------------------+-----------+------------+------------+-------------+

+--------+---------------------------+-----------+------------+------------+-------------+
- + + + +
-

N
2.3.2.1078-2001 ͦ
2.3.2.1293-03 <*>
+--------+---------------------------+-----------+------------+------------+-------------+
in -/- -/+ -/+ -/+
vitro in vivo <*>
+--------+---------------------------+-----------+------------+------------+-------------+
-/- +/+ +/+ -/-
<*>
L--------+---------------------------+-----------+------------+------------+--------------


   --------------------------------

<*> - .

6


()

   -------------------T---------------------T--------------------------------


()


+------------------+---------------------+--------------------------------+

; ; ,
;

,
/
;

+------------------+---------------------+--------------------------------+
-
; ; -
(
)
,

+------------------+---------------------+--------------------------------+


+------------------+---------------------+--------------------------------+

;
; ;

;



+------------------+---------------------+--------------------------------+
, N-
N-, ;
;
-

+------------------+---------------------+--------------------------------+
D(-)-
- D(-)-

L------------------+---------------------+---------------------------------


5.10.8. , / :
- - , , , , ;
- ( ( , ).
5.10.9. , , :
- 1 ( ) ;
- , - () ;
- , - () (, , ) in vitro in vivo.
, () , - () , , 1 .
5.10.10. .
5.10.11. - , / (); , , :
5.10.11.1. . (, , , .) ; , , "ori", .
5.10.11.2. () 16S , - - .
5.10.11.3. : , - , ; , , .
5.10.11.4. , :
- , , - (-);
- , , - ( - );
- , , - .
5.10.11.5. - ( ).
5.10.12. , / , , - - 5 6.
5.10.13. 3 :
1) , , -- ();
2) , -- ();
3) , -- , -- , .
5.10.14. , , :
5.10.14.1. I II ( 1), . 7.

7

,


   -----------T-----------------------T-------------------T------------------



+----------+-----------------------+-------------------+------------------+
1. 1.
I II


1



+-----------------------+-------------------+
2. 2.
/






+-----------------------+-------------------+
3. 3.

,

(,
-
)
+-----------------------+-------------------+
4. 4.
,


(. 5.6.1)
+----------+-----------------------+-------------------+------------------+
1. 1.
I II


1



+-----------------------+-------------------+
2. 2.
/


+-----------------------+-------------------+
3. 3.


(,
-
)
+-----------------------+-------------------+
4. 4.

,






L----------+-----------------------+-------------------+-------------------


5.10.15. , ( I II , , ), :
5.10.15.1. 1 ; , . 5.10.15.2.
5.10.15.2. . , , . 5.10.15.13, , , , . 5.10.15.3, - ( ).
   ------------------------------------------------------------------

--> .
.
   ------------------------------------------------------------------

5.10.15.4. , - - , , - . 5.10.15.5, , . 5.10.15.13.
5.10.15.5. - , . 5.10.15.6, - . 5.10.15.13.
5.10.15.6. ( , , "ori", . 5.10.15.7, - 5.10.15.13.
5.10.15.7. , , , , 5.10.15.13, , 5.10.15.8.
5.10.15.8. , , . 5.10.15.12, , . 5.10.15.13.
5.10.15.9. , , . 5.10.15.12, , . 5.10.15.13.
5.10.15.10. ( -) , , . 5.10.15.12, , . 5.10.15.13.
5.10.15.11. . , . 5.10.15.12, - . 5.10.15.13.
5.10.15.12. , .
5.10.15.13. , , .
5.10.16. II III , , :
5.10.16.1. - . - <*>, , , , . 5.10.16.10, , - . 5.10.16.2.
   --------------------------------

<*> , ( ).

5.10.16.2. , - - , , . 5.10.16.3, , 7.
5.10.16.3. , - (, , ) - (-) . , . 5.10.16.4, , . 5.10.16.10.
5.10.16.4. - / , . , . 5.10.16.9; - , . 5.10.16.5, , . 5.10.16.10.
5.10.16.5. , , , , . 5.10.16.10, , . 5.10.16.6.
5.10.16.6. , -, . 5.10.16.7, , . 5.10.16.9.
5.10.16.7. , , () , , . 5.10.16.9, , . 5.10.16.10.
5.10.16.8. .
5.10.16.9. , .
5.10.16.10. , , .
5.11. , , () .
5.11.1. :
- (/ , ) / , , -, , , - , , ;
- , / :
) (/ , , ), , , ;
) , , / ;
) / () ;
) , , , , / ,
.
   ------------------------------------------------------------------

--> .
.
   ------------------------------------------------------------------

5.13. " " - , , / , ", ()" : "". , " " , :
- " ( )";
- " ( )".
5.12.1. - , / , :
- - () () , ;
- , -, , - - .
5.12.2. - , / , 8.

8

-


   ------------------------------------T-------------------------------------

, ()
(, , .)
+-----------------------------------+-------------------------------------+
1. -
Saccharomyces cerevisiae Y-1986

+-----------------------------------T-------------------------------------+
: -- Saccharomyces cerevisiae Y-1986
- Bacillus
licheniformis 1 x
10
10 / ,
+-----------------------------------+-------------------------------------+
2. - Aspergillus
oryzae
+-----------------------------------T-------------------------------------+
: -- Aspergillus oryzae
-92341
Humicola
lanuginosa
+-----------------------------------+-------------------------------------+
3. - "XXXX" -

+-----------------------------------T-------------------------------------+
: Bacillus amyloliquefaciens . -1
-- - Bacillus
amyloliquefaciens . BZ53 1
-
L-----------------------------------+--------------------------------------


5.13. , / , , 2.18 .

VI. -


( 8, . 21.04.2008 26)

6.1. , , , , , , , , , , , , 95% , , 5% ( ) ( - ), :
- , , , , ( ) ;
- ;
- , , , , ;
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6.3. , , , .
6.4. , ( ) , .
   ------------------------------------------------------------------

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19.07.2011 248- 21 2011 .
   ------------------------------------------------------------------

, , , .
6.5. , " ", , , .
, ( ).
6.6. - -.
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6.7.1. , , , , , , ( - ).
6.7.2. , , , .
, , .
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6.7.4. , , , , , . .
6.7.5. , , . . - .
6.7.6. , 9 10.
6.7.7. , , 11 12.
6.7.8. , , .
6.7.9. , , .
6.7.10. , , 3 / .
6.7.11. . .
6.7.12. , 12 .
6.8. .
6.8.1. , 6 .
, , , , , , .
, .
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6.8.4. , 13 14.
6.8.5. , , 3 - , 11 12 . 170 1 .
6.8.6. , (BSE).
6.8.7. , , , .
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6.8.9. , : , , , , , , , , , , , , , , , , .
6.8.10. , . , ( ..), -- .
6.8.11. , . - , , , 15 .
6.8.12. , (E 200), (E 236), (E 260), (E 270), (E 280), (E 330), , , , , , , , - .
6.8.13. , , ( (E 470), (E 551), (E 558), (E 559), (E 560), , , ), , , - .
6.8.14. , , .
6.8.15. - .

9

,


   ----T-------------------------------------T-------------------------------


/
+---+-------------------------------------+-------------------------------+
1 2 3
+---+-------------------------------------+-------------------------------+
1. (E 170)
2.3.2.1293-03 <*>
+---+-------------------------------------+-------------------------------+
2. (E 220)

2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
3. (270)

2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
4. (E 290)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
5. (E 296)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
6. (E 300)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
7.,
(E 306) 2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
8. (E 322) -
2.3.2.1293-03

+---+-------------------------------------+-------------------------------+
9. (330)
ͦ
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
10. (E 335)
ͦ
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
11. (E 336) ,
,
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
12.- 1-
(E 341i)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
13. (E 400)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
14. (E 401)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
15. (E 402)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
16. (E 406)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
17. (E 407)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
18. (410)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
19. (E 412)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
20. (E 413)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
21. (E 414) ,


2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
22. (E 415)
, ,
,

2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
23. (E 416)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
24. (E 440)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
25. ,
( ) (E 500)

2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
26. (E 501) ,
,

2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
27. (E 503)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
28. (E 504)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
29. (E 508)
,
,
,

2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
30. (E 509) ,
,
,

2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
31. (E 511)

2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
32. (E 516) ,
,

2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
33. (E 524)

2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
34. (E 938)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
35. (E 941)
2.3.2.1293-03
+---+-------------------------------------+-------------------------------+
36. (E 948)
2.3.2.1293-03
L---+-------------------------------------+--------------------------------


   --------------------------------

<*> 2.3.2.1293-03 " ", 02.06.2003, 4613.

10

,



   -----T-------------------------------------T------------------------------


/
+----+-------------------------------------+------------------------------+
1 2 3
+----+-------------------------------------+------------------------------+
1.
+----+-------------------------------------+------------------------------+
2.
+----+-------------------------------------+------------------------------+
3.
+----+-------------------------------------+------------------------------+
4.
+----+-------------------------------------+------------------------------+
5.
+----+-------------------------------------+------------------------------+
6.

+----+-------------------------------------+------------------------------+
7.
+----+-------------------------------------+------------------------------+
8.
+----+-------------------------------------+------------------------------+
9.
+----+-------------------------------------+------------------------------+
10.
+----+-------------------------------------+------------------------------+
11.
+----+-------------------------------------+------------------------------+
12.
+----+-------------------------------------+------------------------------+
13.
+----+-------------------------------------+------------------------------+
14.
+----+-------------------------------------+------------------------------+
15.
+----+-------------------------------------+------------------------------+
16.

+----+-------------------------------------+------------------------------+
17.
+----+-------------------------------------+------------------------------+
18.
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19.
+----+-------------------------------------+------------------------------+
20.
+----+-------------------------------------+------------------------------+
21.
+----+-------------------------------------+------------------------------+
22.
+----+-------------------------------------+------------------------------+
23.
+----+-------------------------------------+------------------------------+
24.
+----+-------------------------------------+------------------------------+
25.
+----+-------------------------------------+------------------------------+
26. pH


+----+-------------------------------------+------------------------------+
27. pH

+----+-------------------------------------+------------------------------+
28.
+----+-------------------------------------+------------------------------+
29.
+----+-------------------------------------+------------------------------+
30.
+----+-------------------------------------+------------------------------+
31. pH

+----+-------------------------------------+------------------------------+
32. pH
L----+-------------------------------------+-------------------------------


11

,
<*>

   -----T---------------------T----------------------------------------------


/
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12


,
<*>

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/
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1 2 3
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1.1. ,
Chrysanthemum
cinerariaefolium, ,


+-----+---------------------------------------+---------------------------+
1.2. ,
Derris elliptica,
Lonchocarpus spp, Thephrosia spp
+-----+---------------------------------------+---------------------------+
1.3. Quassia amara


+-----+---------------------------------------+---------------------------+
1.4. Ryania speciosa


+-----+---------------------------------------+---------------------------+
1.5. ()
Aradiachta indica

+-----+---------------------------------------+---------------------------+
1.6.


+-----+---------------------------------------+---------------------------+
1.7.
(, , , )

+-----+---------------------------------------+---------------------------+
1.8. ,
,
,

+-----+---------------------------------------+---------------------------+
1.9.


+-----+---------------------------------------+---------------------------+
1.10.


+-----+---------------------------------------+---------------------------+
1.11.


+-----+---------------------------------------+---------------------------+
1.12. (, )


+-----+---------------------------------------+---------------------------+
1.13.


+-----+---------------------------------------+---------------------------+
1.14. (Shiitake fungus)


+-----+---------------------------------------+---------------------------+
1.15.


+-----+---------------------------------------+---------------------------+
1.16.


+-----+---------------------------------------+---------------------------+
1.17. (

)
+-----+---------------------------------------+---------------------------+
1.18.


+-----+---------------------------------------+---------------------------+
1.19.


+-----+---------------------------------------+---------------------------+
2.
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2.1. ,
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.



,




+-----+---------------------------------------+---------------------------+
2.2.


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2.3. ( ,
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2.4.


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2.5.


+-----+---------------------------------------+---------------------------+
2.6.


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2.7.


,
+-----+---------------------------------------+---------------------------+
2.8.

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2.9.
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2.11.


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2.12.
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..

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+-----+---------------------------------------+---------------------------+
4.8.


+-----+---------------------------------------+---------------------------+
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5.1.


+-----+---------------------------------------+---------------------------+
5.2.


+-----+---------------------------------------+---------------------------+
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5.4.

.



+-----+---------------------------------------+---------------------------+
5.5.


+-----+---------------------------------------+---------------------------+
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+-----+---------------------------------------+---------------------------+
6.2. - /






.



+-----+---------------------------------------+---------------------------+
6.3.


+-----+---------------------------------------+---------------------------+
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+-----+---------------------------------------+---------------------------+
6.5. ,
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L-----+---------------------------------------+----------------------------


   --------------------------------

<*> .

13

,



   -----T--------------------------------------T-----------------------------


/
+----+--------------------------------------+-----------------------------+
1 2 3
+----+--------------------------------------+-----------------------------+
1. (E 153) ,

2.3.2.1293-03 <*>
+----+--------------------------------------+-----------------------------+
2. (E 170) ,

2.3.2.1293-03.


+----+--------------------------------------+-----------------------------+
3. (E 270) ,

2.3.2.1293-03
+----+--------------------------------------+-----------------------------+
4. (E 290)
2.3.2.1293-03
+----+--------------------------------------+-----------------------------+
5. (E 322), ,

,
, ,

2.3.2.1293-03
+----+--------------------------------------+-----------------------------+
6. (E 331) ,
,
,
2.3.2.1293-03
+----+--------------------------------------+-----------------------------+
7. (E 406)
2.3.2.1293-03
+----+--------------------------------------+-----------------------------+
8. (E 407) ,

2.3.2.1293-03
+----+--------------------------------------+-----------------------------+
9. (E 410)
,
2.3.2.1293-03
+----+--------------------------------------+-----------------------------+
10. (E 412) ,
,
,
2.3.2.1293-03
+----+--------------------------------------+-----------------------------+
11. (E 413)
2.3.2.1293-03
+----+--------------------------------------+-----------------------------+
12. (E 414) ,
,
,

2.3.2.1293-03
+----+--------------------------------------+-----------------------------+
13. ( ) (E 440) ,

2.3.2.1293-03
+----+--------------------------------------+-----------------------------+
14. (E 509) ,

2.3.2.1293-03
+----+--------------------------------------+-----------------------------+
15. (E 938)
2.3.2.1293-03
+----+--------------------------------------+-----------------------------+
16. (E 941)
2.3.2.1293-03
+----+--------------------------------------+-----------------------------+
17. (E 948)
2.3.2.1293-03
L----+--------------------------------------+------------------------------


   --------------------------------

<*> 2.3.2.1293-03 " ", 02.06.2003, 4613.

14

,



   -----T-------------------------------T------------------------------------


/
+----+-------------------------------+------------------------------------+
1 2 3
+----+-------------------------------+------------------------------------+
1. (E 170)
+----+-------------------------------+------------------------------------+
2. (E 509)

+----+-------------------------------+------------------------------------+
3.
+----+-------------------------------+------------------------------------+
4. (E 270)
. pH

+----+-------------------------------+------------------------------------+
5. (E 500)

L----+-------------------------------+-------------------------------------


15

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VII. -



( 14,
.
05.05.2009 28)

7.1. , / , , - , ( - ) () , , 1, , .
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7.5. , , , 2 17 .
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VIII.
,


( 22,
.
27.12.2010 177)

8.1.


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8.2. ,


8.2.1. 18 19 . K2 () L- .
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8.3.


8.3.1. , 15% 50% / . () 20 .
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( 350 100 ) 15% 50% 100 (1 ).
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8.4.


8.4.1. () / , , .
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8.5.4. / , , .





1
2.3.2.1078-01,




14 2001 . 36

1.


( . 2, .
15.04.2003 41,
9, .
23.05.2008 30,
10, .
16.07.2008 43,
11, .
01.10.2008 56,
16, .
27.01.2010 6,
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28.06.2010 71,
22, .
27.12.2010 177,
24, .
01.06.2011 79)

1.1. ;
,

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, ,
/,
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1.1.1. ,
:
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, +---------------T------------------T--------------+
0,01
() 01.01.2012.
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01.01.2012.
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0,02
( . 24, .
01.06.2011 79)
+---------------+------------------+--------------+
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( . 18, .
28.06.2010
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23.05.2008 30)
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/,
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1.1.2.
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1 2 3 4 5 6 7
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1.1.2.1.
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-

,
, ;
L. monocyto-
, genes 25
-

+--------------+---------+----+-----+-----+--------+-------------+
1.1.2.2.
5 15 0,1 1,0 25 - S. aureus
1 -

+--------------+---------+----+-----+-----+--------+-------------+
1.1.2.3.


:
- 2,5 140,1 1,0 25 - S. aureus
Proteus 1
-

- 5 14 0,1 1,0 25 -


()

L--------------+---------+----+-----+-----+--------+--------------


   ---------------T---------------T------------------T--------------

, ,
/,
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( 10, . 16.07.2008 43)
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-, -, -, / , / , / , / ,
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+--------+------+-------+--------+--------+-------+--------+-------+---------+--------+------+--------+-------+
- 10,0 >= 200 6,3 - 0,8 - <= 10 20 - 50 20 - 50 1 10 - 50 - <= 30 1300 -
17,0 3,0 2500
+--------+------+-------+--------+--------+-------+--------+-------+---------+--------+------+--------+-------+
- 9,5 >= 200 8,0 - 0,2 - <= 10 20 - 50 20 - 500,9 - 5 - 40 - <= 30 900 -
20,0 12,0 1,02 2000
+--------+------+-------+--------+--------+-------+--------+-------+---------+--------+------+--------+-------+
10,0 - 0,05 - > 3,0 <= 20 45 - 85 15 - 350,3 - 5 - 30 2,5 - <= 30 900 -
0,2 0,5 7,0 1500
+--------+------+-------+--------+--------+-------+--------+-------+---------+--------+------+--------+-------+
- 13,5 - 0 - 2,5 - <= 20 60 - 11060 - 1,0 - <= 30 900 -
0,5 7,0 110 2000
<*>
+--------+------+-------+--------+--------+-------+--------+-------+---------+--------+------+--------+-------+
- 11,2 >= 50 3,0 - 1,0 - <= 20 15 - 40 15 - 400,8 - 25 - 80 - <= 30 900 -
11,0 4,0 1,1 2000
+--------+------+-------+--------+--------+-------+--------+-------+---------+--------+------+--------+-------+
- 10,2 - 1,5 - 5 - 20 <= 20 10 - 45 15 - 501,0 - < 55 1,5 - <= 35 2000 -
(11,2) 16,0 2,5 10 4000
()
+--------+------+-------+--------+--------+-------+--------+-------+---------+--------+------+--------+-------+
5,0 - 2,0 - 0,1 - <= 20 12 - 18 10 - 160,8 - < 1 - <= 100 1500 -
5,0 0,6 1,0 3500
+--------+------+-------+--------+--------+-------+--------+-------+---------+--------+------+--------+-------+
11,6 >= 750 26,0 - 1 - 4 <= 20 30 - 65 23 - 500,6 - 0 - 5 - <= 30 2300 -
- 42,0 0,9 4100
(-
)
+--------+------+-------+--------+--------+-------+--------+-------+---------+--------+------+--------+-------+
13,5 - 0,0 - 15,5 - <= 20 32 - 60 35 - 701,0 - 10 - <= 30 1600 -
0,4 27,0 1,35 35 3500
+--------+------+-------+--------+--------+-------+--------+-------+---------+--------+------+--------+-------+
- 10,0 - 1,5 - 2,0 - <= 20 10 - 32 7,5 - 0,8 - 12 - 60 1 - 5 <= 35 1400 -
5,0 6,0 25 1,0 3300
+--------+------+-------+--------+--------+-------+--------+-------+---------+--------+------+--------+-------+
- 7,0 - 5 - 11 0,6 - <= 20 18 - 40 15 - 350,75 - < 10 < 0,25<= 40 1300 -
5,0 1,0 2800
+--------+------+-------+--------+--------+-------+--------+-------+---------+--------+------+--------+-------+
11,9 - < 4,0 0,8 - <= 20 50 - 90 10 - 35< 0,4 0 - 15 - <= 30 1000 -
5,0 2000
+--------+------+-------+--------+--------+-------+--------+-------+---------+--------+------+--------+-------+
8,0 >= 150 45 - 63 1,0 - <= 20 3 - 12 3 - 11 0,9 - < 7,0 - <= 30 1100 -
7,5 1,3 2000
L--------+------+-------+--------+--------+-------+--------+-------+---------+--------+------+--------+--------


   --------------------------------

<*> 2,0 - 7,0 /.





3
2.3.2.1078-01,




14 2001 . 36

3.


( . 2, .
15.04.2003 41,
10, .
16.07.2008 43,
11, .
01.10.2008 56,
18, .
28.06.2010 71,
22, .
27.12.2010 177,
24, .
01.06.2011 79)

3.1.

3.1.1.

3.1.1.1. (, , )

1) ( )

( . 10, . 16.07.2008 43)

   ----------------------T---------T-----------------------T--------

-

+---------------------+---------+-----------T-----------+--------+

+---------------------+---------+-----------+-----------+--------+
1 2 3 4 5
+---------------------+---------+-----------+-----------+--------+
0 5
+---------------------T---------T-----------T-----------T--------+
<1> / 12 - 17 +
+---------------------+---------+-----------+-----------+--------+
% 50 +

-
,

+---------------------+---------+-----------+-----------+--------+
/ 40 - 60 +
+---------------------+---------+-----------+-----------+--------+
<2> / 30 - 40 +
+---------------------+---------+-----------+-----------+--------+
% - 14 - 20 +


+---------------------+---------+-----------+-----------+--------+
/ 4000 - 8000 -
+---------------------+---------+-----------+-----------+--------+
- - 1 - 2 -
/
+---------------------+---------+-----------+-----------+--------+
<3> / 65 - 80 +
+---------------------+---------+-----------+-----------+--------+
% - 65 +
-

-
,

+---------------------+---------+-----------+-----------+--------+
/ 640 - 700 +

+---------------------+---------+-----------+-----------+--------+
:
+---------------------T---------T-----------T-----------T--------+
/ 330 - 700 +
+---------------------+---------+-----------+-----------+--------+
/ 150 - 400 +
+---------------------+---------+-----------+-----------+--------+
- 1,2 - 2,0 -
/
+---------------------+---------+-----------+-----------+--------+
/ 400 - 800 +
+---------------------+---------+-----------+-----------+--------+
/ 150 - 300 +
+---------------------+---------+-----------+-----------+--------+
- 2,5 - 3 -
/
+---------------------+---------+-----------+-----------+--------+
/ 30 - 90 +
+---------------------+---------+-----------+-----------+--------+
/ 300 - 600 +
+---------------------+---------+-----------+-----------+--------+
/ 10 - 300 +
+---------------------+---------+-----------+-----------+--------+
/ 3 - 9 +
+---------------------+---------+-----------+-----------+--------+
/ 3 - 10 +
+---------------------+---------+-----------+-----------+--------+
/ 300 - 800 -
+---------------------+---------+-----------+-----------+--------+
/ 50 - 150 +
+---------------------+---------+-----------+-----------+--------+
/ 10 - 40 +
+---------------------+---------+-----------+-----------+--------+
/ 2,5 - 4,0 +
+---------------------+---------+-----------+-----------+--------+
:
+---------------------T---------T-----------T-----------T--------+
(A) -/400 - 1000 +
+---------------------+---------+-----------+-----------+--------+
(E) / 4 - 12 +
+---------------------+---------+-----------+-----------+--------+
() / 7,5 - 12,5 +
+---------------------+---------+-----------+-----------+--------+
K / 25 - 60 +
+---------------------+---------+-----------+-----------+--------+
(B1) / 0,4 - 2,1 +
+---------------------+---------+-----------+-----------+--------+
(B2) / 0,5 - 2,8 +
+---------------------+---------+-----------+-----------+--------+
/ 2,7 - 14,0 +
+---------------------+---------+-----------+-----------+--------+
(B6) / 0,3 - 1,0 +
+---------------------+---------+-----------+-----------+--------+
(PP) / 2,0 - 10,0 +
+---------------------+---------+-----------+-----------+--------+
/ 60 - 350 +
(Bc)
+---------------------+---------+-----------+-----------+--------+
(B12) / 1 - 3 +
+---------------------+---------+-----------+-----------+--------+
/ 55 - 150 +
(C)
+---------------------+---------+-----------+-----------+--------+
/ 20 - 280 +
+---------------------+---------+-----------+-----------+--------+
/ 50 - 350 +
+---------------------+---------+-----------+-----------+--------+
/ 10 - 40 +
+---------------------+---------+-----------+-----------+--------+
L- / 10 - 20 +
+---------------------+---------+-----------+-----------+--------+
( /, 35 +
-, -,
-, -
-5
)
+---------------------+---------+-----------+-----------+--------+
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<4> 1 x 10 -

( -
-

-
-
)
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1 x 10
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7 +
<4> 1 x 10
+---------------------+---------+-----------+-----------+--------+
/ 290 - 320 +
+---------------------+---------+-----------+-----------+--------+
0 90 - -
, -
-
-

+---------------------+---------+-----------+-----------+--------+
5 12
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<1> / 12 - 21 +
+---------------------+---------+-----------+-----------+--------+
% - 35 +
-

,

+---------------------+---------+-----------+-----------+--------+
<2> / 25 - 40 +
+---------------------+---------+-----------+-----------+--------+
% - 14 - 20 +


+---------------------+---------+-----------+-----------+--------+
/ 4000 - 8000 -
+---------------------+---------+-----------+-----------+--------+
<3> / 70 - 90 +
+---------------------+---------+-----------+-----------+--------+
% - 65 +
-

-
,

+---------------------+---------+-----------+-----------+--------+
/ 640 - 750 +

+---------------------+---------+-----------+-----------+--------+
:
+---------------------T---------T-----------T-----------T--------+
/ 400 - 900 +
+---------------------+---------+-----------+-----------+--------+
/ 200 - 600 +
+---------------------+---------+-----------+-----------+--------+
/ - 1,2 - 2,0 -

+---------------------+---------+-----------+-----------+--------+
/ 500 - 900 +
+---------------------+---------+-----------+-----------+--------+
150 - 300 +
+---------------------+---------+-----------+-----------+--------+
/ - 2 - 3 -

+---------------------+---------+-----------+-----------+--------+
/ 50 - 100 +
+---------------------+---------+-----------+-----------+--------+
/ 400 - 1000 +
+---------------------+---------+-----------+-----------+--------+
/ 10 - 300 +
+---------------------+---------+-----------+-----------+--------+
/ 7 - 14 +
+---------------------+---------+-----------+-----------+--------+
/ 4 - 10 +
+---------------------+---------+-----------+-----------+--------+
/ 300 - 800 -
+---------------------+---------+-----------+-----------+--------+
/ 50 - 350 +
+---------------------+---------+-----------+-----------+--------+
/ 10 - 40 +
+---------------------+---------+-----------+-----------+--------+
/ 2,5 - 6,0 +
+---------------------+---------+-----------+-----------+--------+
:
+---------------------T---------T-----------T-----------T--------+
(A) -/ 400 - 800 +
+---------------------+---------+-----------+-----------+--------+
(E) / 4 - 12 +
+---------------------+---------+-----------+-----------+--------+
() / 8 - 21 +
+---------------------+---------+-----------+-----------+--------+
K / 25 - 170 +
+---------------------+---------+-----------+-----------+--------+
(B1) / 0,4 - 2,1 +
+---------------------+---------+-----------+-----------+--------+
(B2) / 0,5 - 2,8 +
+---------------------+---------+-----------+-----------+--------+
/ 3,0 - 14,0 +
+---------------------+---------+-----------+-----------+--------+
(B6) / 0,4 - 1,2 +
+---------------------+---------+-----------+-----------+--------+
(PP) / 3,0 - 10,0 +
+---------------------+---------+-----------+-----------+--------+
/ 60 - 350 +
(Bc)
+---------------------+---------+-----------+-----------+--------+
(B12) / 1,5 - 3,0 +
+---------------------+---------+-----------+-----------+--------+
/ 55 - 150 +
(C)
+---------------------+---------+-----------+-----------+--------+
/ 50 - 350 +
+---------------------+---------+-----------+-----------+--------+
/ 10 - 40 +
+---------------------+---------+-----------+-----------+--------+
/ 20 - 280 +
+---------------------+---------+-----------+-----------+--------+
L- / 5 - 20 -
+---------------------+---------+-----------+-----------+--------+
( /, 35 +
-, -,
-, -
-5
)
+---------------------+---------+-----------+-----------+--------+
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<4> 1 x 10 -

( -
-

-
-
)
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1 x 10
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<4> 1 x 10
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/ 290 - 320 +
+---------------------+---------+-----------+-----------+--------+
0 90 - -
, -
-
-

+---------------------+---------+-----------+-----------+--------+
0 12
+---------------------T---------T-----------T-----------T--------+
<1> / 12 - 21 +
+---------------------+---------+-----------+-----------+--------+
% - 50 +
-

,

+---------------------+---------+-----------+-----------+--------+
/ 40 - 60 +
+---------------------+---------+-----------+-----------+--------+
<2> / 30 - 40 +
+---------------------+---------+-----------+-----------+--------+
% - 14 - 20 +


+---------------------+---------+-----------+-----------+--------+
/ 4000 - 8000 -
+---------------------+---------+-----------+-----------+--------+
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/
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+---------------------+---------+-----------+-----------+--------+
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-

-
,

+---------------------+---------+-----------+-----------+--------+
/ 640 - 720 +

+---------------------+---------+-----------+-----------+--------+
:
+---------------------T---------T-----------T-----------T--------+
/ 400 - 900 +
+---------------------+---------+-----------+-----------+--------+
/ 200 - 600 +
+---------------------+---------+-----------+-----------+--------+
/ - 1,2 - 2,0 -

+---------------------+---------+-----------+-----------+--------+
/ 400 - 800 +
+---------------------+---------+-----------+-----------+--------+
/ 150 - 300 +
+---------------------+---------+-----------+-----------+--------+
/ - 2,5 - 3 -

+---------------------+---------+-----------+-----------+--------+
/ 40 - 100 +
+---------------------+---------+-----------+-----------+--------+
/ 300 - 1000 +
+---------------------+---------+-----------+-----------+--------+
/ 10 - 300 +
+---------------------+---------+-----------+-----------+--------+
/ 6 - 10 +
+---------------------+---------+-----------+-----------+--------+
/ 3 - 10 +
+---------------------+---------+-----------+-----------+--------+
/ 300 - 800 -
+---------------------+---------+-----------+-----------+--------+
/ 50 - 350 +
+---------------------+---------+-----------+-----------+--------+
/ 10 - 40 +
+---------------------+---------+-----------+-----------+--------+
/ 2,5 - 6,0 +
+---------------------+---------+-----------+-----------+--------+
:
+---------------------T---------T-----------T-----------T--------+
(A) -/ 500 - 800 +
+---------------------+---------+-----------+-----------+--------+
(E) / 4 - 12 +
+---------------------+---------+-----------+-----------+--------+
(D) / 8 - 21 +
+---------------------+---------+-----------+-----------+--------+
K / 25 - 170 +
+---------------------+---------+-----------+-----------+--------+
(B1) / 0,4 - 2,1 +
+---------------------+---------+-----------+-----------+--------+
(B2) / 0,5 - 2,8 +
+---------------------+---------+-----------+-----------+--------+
/ 2,7 - 14,0 +
+---------------------+---------+-----------+-----------+--------+
(B6) / 0,3 - 1,2 +
+---------------------+---------+-----------+-----------+--------+
(PP) / 3,0 - 10,0 +
+---------------------+---------+-----------+-----------+--------+
/ 60 - 350 +
(Bc)
+---------------------+---------+-----------+-----------+--------+
(B12) / 1,5 - 3,0 +
+---------------------+---------+-----------+-----------+--------+
/ 55 - 150 +
(C)
+---------------------+---------+-----------+-----------+--------+
/ 20 - 280 +
+---------------------+---------+-----------+-----------+--------+
/ 50 - 350 +
+---------------------+---------+-----------+-----------+--------+
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L- / 5 - 20 +
+---------------------+---------+-----------+-----------+--------+
( /, 35 +
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-, -
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)
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<4> 1 x 10 -

( -
-

-
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1 x 10
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+---------------------+---------+-----------+-----------+--------+
/ 290 - 320 +
+---------------------+---------+-----------+-----------+--------+
0 90 - -
, -
-
-

L---------------------+---------+-----------+-----------+---------


   --------------------------------

:
<1> - ;
<2> - ;
- 3% ;
20% ;
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1% w-3 2% w-6 ;
;
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0,02
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3.1.1.2. , (, , )

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30 - 80 +
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+---------------------+---------+-----------+-----------+--------+
:
() -/ 600 - 800 +
() / 5 - 12 +
() / 10 - 12 +
(1) 400 - 800 +
(2) 600 - 1000 +
2500 - 3500 +
(6) 500 - 700 +
() 4000 - 8000 +
50 - 150 +
()
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L----------------------------+------------------+-----------------


3.1.1.3. ( .. )

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-


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115 - 140 +
90 - 120 +
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